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The reading frame was preserved in both mutations, yet the phenotype in each case was severe peripheral neuropathy.
The frequency of the risk SNP alleles tended to increase with the severity of the RET mutations, yet the small sample does not allow to draw any conclusion (Table 3).
Previous analyses of whole human genomes have shown that SVs affect more base pairs than single point mutations, yet the field has struggled to find a suitable approach for comprehensive detection of such events [ 30].
The 9q31 locus segregated in families of European descent harbouring no or hypomorphic RET mutations, yet the families still showed linkage to 10q12 (RET locus) (Bolk et al. 2000b).
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Others have attempted to determine clonality based on the presence of concordant mutations, yet this methodology can be limited by the fact that sporadic mutations happen recurrently at the same point in some tumors.
N.C.: With the neuraminidase inhibitors, we don't know the full range of mutations yet that can confer resistance.
A novel in-house developed bioinformatics tool enabled identification of SNMs and RNMs that exhibit similar characteristics as do disease-causing mutations, yet unlike the latter, survived natural selection over time and hence, are likely adaptive.
PRCV differs from TGEV by a small deletion and a couple point mutations, yet it infects the pig respiratory system and is often much less virulent than TGEV.
The fact that NP sequences are available for every year since 1968 allows us to reconstruct the trajectory with remarkable precision: there are >10 possible orderings of 39 mutations, yet we can confidently identify the sequences of 25 of the evolutionary intermediates; the remainder fall along regions of the trajectory where two or more mutations occurred in an unknown order.
In contrast, two isolates from patient 17 collected 127 days apart differed by nine-point mutations, yet clustered together in the phylogenetic tree (figure 2).
CI is a process concerning adaptive mutations, yet we did not measure the fitness effects for most of the individual mutations observed in this experiment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com