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Two forces, recombination and accumulation of deleterious mutations, would tend to act against the selection for globally elevated mutation rates.
It would make sense that our approach automatically made an entropy adjustment, because the random mutations would tend to 'smooth out' the information across the (augmented) training set.
At the same time, such genes cannot be ubiquitously expressed because in such cases disruptive mutations would tend to cause embryonic lethality.
In such genes, as surmised by Wilson et al. (1977), even subtle amino acid mutations would tend to lead to sufficiently strong deleterious effects to be noticed by natural selection.
In a neutrally evolving region, older mutations would tend to be in higher frequencies than new mutations [ 49], that is why we performed a contrast between synonymous and non-synonymous mutations using a non-parametric Mann-Whitney test which investigated the pattern of differential survival between synonymous and nonsynonymous in evolutionary time (Table 6).
Similar(55)
Rather, they are conserved because a mutation in such a buried residue would tend to perturb the architecture.
At the same time, disruptive mutations in functionally important but widely expressed genes would tend to lead to embryonic lethality instead of disease.
In principle, epistasis would tend to 0 when the two mutations fall down in the sequence with sufficient separation so that their effects are uncorrelated.
It decouples neutral variation from linked deleterious mutations that are consistently eliminated by selection, and from beneficial variants, which would tend to be fixed [ 2].
Metabolic rate and generation time (both correlated with body size) may affect mutation rates by altering the mean residence times of nucleotides, such that these would tend to be shorter in small, short-lived and metabolically active species [16].
A mutation in ahpC might indirectly up-regulate katA expression through relief of PerR repression, a compensatory response that would tend to restore H2O2 resistance.
More suggestions(15)
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