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Gene mutations would result in observable differences - in cell patterns or in simple forms of behaviour, such as moving, eating, excreting or mating - and more or less linear relationships between genes and phenotype (the form of an organism) could be established.
A virus crippled by immune escape mutations would result in reduced viral load and delayed disease.
In contrast, comparing the wt and mutants to one another and parameterizing the simulation using a geometric parameter, i.e. the degree of solvation of the buried interface, resulted in a testable prediction regarding which mutations would result in a stable dimer.
In one study, it was shown that LGI1 affects postnatal maturation of glutamatergic synapses, a process involving ADAM22, and mediates dendrite pruning so that LGI1 mutations would result in persistence of immature, untrimmed, dendritic arbor [15].
Given the critical importance of translation, one might expect that each of these mutations would result in severe multi-systemic disorders.
Thus, molecular modeling suggests that both mutations would result in a higher calcium concentration threshold for activation of the catalytic subunit of calmodulin.
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Subsequent next-generation sequencing identified a nonsense mutation in AGBL1 in the 15q locus; this mutation would result in a premature termination of AGBL1.
This mutation would result in out-of-frame, continued translation into the 3′-untranslated region (p.Tyr335Glyfs*113).
It used to be assumed that this mutation would result in active Rab enzymes.
Our energy results showed the R213W mutation would result in destabilization but the standard deviation is significant.
If N17 acts as an LR-NES, then L4A mutation would result in the loss of hydrophobicity at the Φ0 position (Fig. 1A).
More suggestions(15)
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mutations would boost
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mutations would multiply
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