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If, as is likely, Smc1 M665R and Smc3 M577K increase hinge dissociation, even if only transiently, then the mutations would permit escape of chromatin fibers that had previously been entrapped by mutant complexes.
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The rate at which mutations are eliminated would permit estimation of the strength of selection against them.
Hence, they would permit the mutation discovery in DNA sequences (see [ 1]).
This result parallels the above replication phenotype, where the G28A mutation only enhanced HCV replication in cells in which miR-122 activity is low, and suggests that an A at position 28 may enhance miR-122 accessibility or binding to HCV RNA, which would permit this mutant to replicate efficiently with fewer bioavailable miR-122 molecules.
The Typhimurium model would permit a degree of experimental flexibility in understanding these mutations in greater detail, but may not precisely reflect the effects seen during acute typhoid fever in humans.
That would permit higher yields.
Your reasoning would permit that….
"But your reasoning would permit that," Kennedy followed up.
The E.P.A.'s decision would permit, but not require, E15.
I would permit a married clergy.
The proposed change would permit more disclosure.
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