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Exact(6)
But what mutations would make the virus more easily transmissible?
"We have no idea whether these mutations would make other influenza viruses more pathogenic or transmissible," he says.
Genetic mapping of the mutations would make it possible to compare gene positions and to determine whether different loci were involved.
For this reason, I do not think that introduction of mutations would make much difference to the major conclusions made above about the likely pathways of evolution of the code.
How many mutations would make an avian virus capable of infecting humans efficiently, or how many mutations would render an influenza virus a pandemic strain, is difficult to predict.
The half-life of Fc-fusions is typically shorter than intact Abs (1 2 weeks against 3 4 weeks; Suzuki et al, 2010), and so it might be expected that equivalent mutations would make a more significant effect on the half-lives and overall efficacy of Fc-fusions than mAbs.
Similar(54)
One may naively assume that a proline to threonine mutation would make the backbone more flexible, and one may observe the conformational equilibrium in the mutant.
The maps are also a reminder of the "unceasing mutations" that would make today's Manhattan largely unrecognizable to an early-19th-century surveyor.
The rationale is that a large mutation rate would make the GA search to resemble a random search.
For example, if some other resource is able to link proteins to pathways, combining it with our pipeline (that can link mutations to proteins) would make it possible to find a pathway in which a mutated protein participates.
Although the real-time PCR assays were able to detect as little as 0.001% 0.2% cloned mutant sequences, increasing ΔCT cutoffs to expand the mutation detection range would make it difficult to differentiate drug-selected mutants from naturally-occurring variants.
More suggestions(15)
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