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It suggested that the additive effects of combinatorial mutations would depend much on the context of the mutated residues even in pyranose oxidase homologs with high amino acid sequence similarity.
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13 Although this finding suggests that mutations conferring artemisinin resistance could spread to parasite populations in contiguous geographic areas, this possibility would depend on the fitness cost of the mutations as well as parasite population structure and gene flow.
Thus, the potential therapeutic efficacy of an HDAC8 activator in the management of CdLS would depend on the specific HDAC8 mutation involved.
This means that the classic genotype – phenotype concept cannot be applied to mutations in many housekeeping genes since the resulting phenotype would depend on p53.
More realistic estimates would depend on studies of the neutral mutation rate and generation time of B. burgdorferi in the wild.
Dr. Vogelstein said he believed the technique could help many tests for flawed genes that promote diseases, although the amount of improvement would depend on the nature of the genes and mutations involved.
The extent to which any such conversion processes violate the SMM would depend on the relative rates of gene conversion and stepwise mutation.
It would depend what my partner believed.
The awkwardness would depend on the context.
That would depend on the circumstances.
"It would depend," Ms. Brinkmann replied.
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