Both Nietzsche and the mathematician Poincare believed in the notion of Eternal Recurrence which states that over the infinite expanse of time literally everything and all its mutations would appear as a succession of possibilities.
29 Targeting the screening of a specific panel of genes known to be associated with a particular phenotype, as opposed to screening mutations, would appear necessary in the belief that eating five pieces of fruit and vegetables a day will keep us slim, healthy, and disease free.
For instance, the mutation would appear not to be useful towards survival of its possessors (oxygen deprivation and clogged capillaries) and it is not in malaria-free areas but it is the difference between life (and reproductive success) and death in areas of malarial infestation.
This mutation would appear not to influence the development of the attenuation loop.
Given the distribution of the mutations, it would appear unlikely that there is a unifying molecular mechanism linking them.
In addition, selective sweep reduces variability around a selected site: new mutations would gradually appear at low frequencies, eventually causing a frequency spectrum (Oleksyk et al. 2010).
In reality, a deleterious gene would appear through mutation in an individual, and the result, at most, may be the elimination of the individual together with the gene in the population, rather than a system-wide collapse.
Thus, it would appear that somatic mutations are likely an epiphenomena and/or constitute events that occur after carcinogenesis has begun [14, 15, 41, 42], as there are also cancers which are not associated with mutations [43, 44].
It would appear that PDB mutations can perturb these equilibria in a manner that both directly and indirectly affects the binding affinity of the active monomer.
Thus, it would appear that many mutations are, on their own, insufficient to cause disease and need to occur in the presence of other genetic variants, either allelic or non-allelic, as well as facultative environmental factor(s), for a disease state to ensue.
It would appear that BRCA1 mutation carriers have substantially better survival when treated with chemotherapy, and even small node-negative tumours should be treated.
