Sentence examples for mutations without the from inspiring English sources
The ability to obtain the desired mutations without the use of a selectable marker obviates concerns about the confounding impact of such an exogenous, independent transcription unit.
In this system, the duplicated gene is freed to suffer random mutations without the counter force of negative selection.
This is because some systems annotated mutations without the prefix "p ., which was annotated in the Variome corpus, e.g. p.Lys618Ala.
Furthermore, the inflexible nature of the transgene prohibits the introduction of new tau mutations without the generation of an entirely new transgenic line.
We show here that WGS/SNP mapping is an efficient method to map suppressor mutations without the need for previous phenotypic characterization.
This accumulation of deleterious mutations without the chance to reduce them again in organisms without meiotic recombination has been termed Muller's ratchet [ 70, 71], and has been shown to lead to an increased extinction risk in asexual organisms [ 72].
In other words, population subdivision increases the conversion of the least-loaded class by HGT in the direction of both increasing and decreasing the number of mutations without changing the magnitude and direction of the net conversion.
Duplicated genes give organisms the opportunity to "experiment" with mutations without losing the biological function of the original gene because when one copy experiences a deleterious mutation that destroys its function, the other copy can still be functional.
Furthermore, within individual genomes, less highly conserved sites may point to regions that can tolerate mutations without affecting the fitness of the individual, whereas mutations at more highly conserved sites may be lethal.
The sum of the diagonal elements determines the fraction of the mutations without impact on the dynamics.
Moreover, it is very plausible that some carcinogens influence the rate of accumulation of mutations without altering the pattern (Biggs et al. 1993).
