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This averaging eliminates information on correlated mutations within each protein structure.
In contrast, clusters 1 and 2 are enriched for cells with EGFR mutations; within each of these clusters, cells with wt and mutant EGFR are segregated.
We detected negligible numbers of predicted stem structures formed by the ancient mammalian-wide interspersed repeats (MIR repeats from SINE class) presumably because they have accumulated too many mutations within each repetitive element to be adequately paired.
The locations of the mutations within each target locus responsible for base composition changes observed in the 2005 2006 northern isolates were verified by direct sequencing of the PCR products (results shown in Table S3) and confirmed the findings described above.
Distance between in mutations within each sample.
The number of disabling mutations within each pseudogene is given in columns 2 and 3.
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After the selection, crossover of the genes between two randomly selected samples occurs with a given probability, followed by the mutation within each gene that occurs with a given probability, in order to generate the samples of the next generation.
Whilst there is some evidence of variation of cancer risk by position of mutation within each gene [ 10- 12], more variation occurs between families with the same mutation.
We used the HKY85 [ 30] substitution model to describe mutation within each locus with κ = 2.5 for the nuclear loci and κ = 15 for the mtDNA.
Either this reflects the incomplete annotation of the bovine genome, or the fact that the selected functional mutation within each of these regions is not located within a protein coding gene.
In agreement with this, we found that the best variable for shear force on chromosome 7 was that for a conventional SNP test, with frequencies close to the frequencies of the mutation within each subspecies (i.e. 0.9 in B. taurus and 0.76 in B. indicus).
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