In both of the experiments, as in Fig 2B, the mutated primer contained two mutations within a 3 bp region.
Statistical analyses of mutational biases were performed by pooling microsatellite mutations within a given vector observed among all cell clones, followed by Fisher exact test (two-sided).
Studies of mutational composition of individual cells showed that accumulation of mutations within a cell usually does not occur via accrual of random hits.
Rarity of clonal mutations within a region does not, however, rule out selection in that region.
Oncogenic mutations within a subclone are likely to play a crucial role in cancer recurrence, metastasis, and chemoresistance.
This approach generated mosaic genetic mutations within a wild-type cellular background.
The PIPseq program identifies the molecular drivers of each patient's cancer the mutations within a gene that promote cancer development.
Sun, X. et al. Niemann Pick C variant detection by altered sphingolipid trafficking and correlation with mutations within a specific domain of NPC1.
While recombination can bring together multiple mutations within an organism, evolution in asexual populations depends on the sequential accumulation of mutations within a lineage.
A Russian-born geneticist and computer scientist, Olga Troyanskaya, who is also a professor at Princeton, told Simons about an algorithm she was developing, which would predict the effects of specific mutations within a given cell.
Traditional carrier screening assays are designed to look for only the most common mutations within a gene owing to cost considerations.
