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Contrary to our intuition, the effects of deleterious mutations have little impact on this rate as long as there is no an abundance of deleterious mutations with tiny effects.
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By considering the present genomic compositions as a snapshot of dynamic transitions, the paradoxes of isochore are explained under the variable model: that is, a local genomic composition can occasionally converge on a certain GC content value and occasionally can diverge with tiny changes of mutation patterns.
Thus, in the near future, we are to choose one of the alternative cases: (1) a case in which SZ should have many susceptibility genes with tiny effects of exceptionally high mutation rates, or (2) a case in which SZ should have many resistance genes of standard mutation rates on different chromosomes associated with SZ itself.
The illnesses, many of which affect the brain and muscles and worsen as children grow, are produced by genetic mutations in tiny structures called mitochondria that sit inside cells and provide them with energy.
Or rollerskates with tiny wheels.
Dealers are increasingly replacing vials with tiny Ziploc plastic bags.
Then spelt with tiny artichokes and white truffle.
Dogs with tiny hats.
Things with tiny dimples?
The world of microbes is teeming with tiny killers.
They impaled these cells with tiny electrodes made of glass.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com