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Kawaoka's group carried out a series of experiments that coaxed out additional mutations with that effect.
To distinguish driver from passenger mutations, Greenman et al. used a statistical model comparing the observed-to-expected ratio of synonymous (no amino-acid change) mutations with that of non-synonymous (altered amino acid) mutations.
We compared the survival of men with BRCA2 mutations with that of men with BRCA1 mutations.
The analysis described here can be generalized to other alterations by substituting the multiplicity of somatic mutations with that of copy number, methylation, or microarray data.
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This was a case control study comparing tamoxifen history in bilateral breast cancer patients with a BRCA1 or BRCA2 mutation with that in unilateral patients, also with a mutation.
Combinations of these mutations with others that lead to a reverse phenotype or altered inducer specificity yielded new TetR mutants with the respective combined activities.
Mutations with descriptions that did not match any of the given strings were discarded from further analysis.
Methylation mosaics: This term refers to full mutations with subpopulations that remain unmethylated.
Purifying selection is weaker for mutations with effects that are only mildly deleterious.
There was an excess of unique mutations compared with that expected for a constant-size population (Table 2).
Our observation that amplification of multiple products derived from homeologous templates reduces the ability to detect mutations agrees with that of Slade and colleagues [ 18].
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