Sentence examples for mutations with strong from inspiring English sources

However, Hamilton's rule [73], [74] does not account for low frequency mutations with strong selective effects and therefore, relatedness alone is not always a good predictor of kin conflict over reproduction [75], [76].

In particular, a strong emphasis should also be placed on APOL1 mutations with strong association and functional plausibility.

We have also screened breast/ovarian patients with a family history for two mutations with strong founder effects, 22 patients for 185delAG and 26 patients for 5382insC.

Laboratory experiments either manipulate Hsp90 activity pharmacologically, or they induce mutations with strong effects in the gene Hsp83, the single-copy fly gene encoding Hsp90.

So, in theory, it would seem that most mutations with strong potential to affect DNA flexibility would be less likely to alter amino acid sequences of proteins.

Among other hypotheses, we discuss the maintenance of heritable variation by few mutations with strong epistatic interactions whose effects are modified by continuous changes of the genetic background through time.

We assign a score to every possible non-silent mutation according to its expected impact on the protein function: higher score for mutations with stronger impact.

The authors found that "eventual winners" had, indeed, the ability to generate beneficial mutations with stronger effects, compared with the "eventual losers".

If a rare mutation with strong influence on the pathway level gene expression is combined with little influence, the latter might be falsely called as significant, due to its influential partner, while it is not truly contributing to the pathway level gene expression change.

Here we consider the category that contains mutations with very strong effects (see background selection theory [ 113, 114]).

And second, screening of Mendelian families or de novo cases has identified rare mutations with a strong predicted impact on channel function.