Sentence examples for mutations with significant from inspiring English sources
There were four mutations with significant differences in mutant allele frequency between the three panels (Table 3).
The authors argue that mutations with significant "conditional Ka/Ks values" are not directly involved in the drug resistance and play accessory role.
Somatic DNA mutations with significant predicted effects on protein function (according to Mutation Assessor) were found in only 2 samples (Table 1).
In contrast, mutations with significant deleterious effects on fertility (e.g. in some cases of severe autism) are less frequently transmitted to subsequent generations.
There was a significant difference between the frequency of EGFR T790M and other EGFR-activating mutations, with significant variability among cases (4.8 41.3 %).
This survey was later expanded to 210 cancer samples and it revealed more than 1 000 somatic mutations with significant variations in their patterns across the examined twelve cancer types [ 24].
We report a case of a 52 year old female with bilateral advanced adenocarcinoma of the lung harboring the delE709_T710insD mutation with significant clinical and radiographic response to treatment with afatinib.
In order to find this rare mutation with significant reproducible results, many family members and matched controls are necessary.
Although the pig IGF2 gene has been characterised in detail including the identification of a point mutation with significant effects on muscling [ 24], there is only a fragment of the gene in the published pig genome sequence (Sscrofa10.2; [ 12]).
Imatinib is a small molecule inhibitor of KIT that inhibits proliferation and induces apoptosis in melanoma cells harbouring KIT mutations, associated with significant clinical response in these patients [46].
In Figure 6A, it is very clear that Mendelian disease-related variants (SVD) occur at positions where amino acids are relatively conserved compared with those from polymorphic datasets (SVP and SAP) and cancer somatic mutations (CSM) with significant differences in the distribution (P<1.0−11).
