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Moreover, genes with more exons tend to have more co-occurring mutations with other genes, and genes having lower local coherent network structures tend to have higher mutation frequency.
In all three patients, the initial selection of the N155H mutation was followed by its disappearance and replacement by a pattern comprising the Y143H/R/C mutations with other mutations (T97A in 3 patients, L74M in 2 patients and G163R and S230R in one patient each); RAL was stopped between months 6 and 12 in patient 1, with disappearance of the selected mutations.
In addition, the interaction of TP53 mutations with other genetic alterations in AML was largely unknown.
The association of TERT promoter mutations with other molecular alterations commonly seen in glioma is detailed in Supplementary Table 5 and Supplementary Figure 1.
COSMICMart (COSMIC BioMart) provides a flexible way to mine these data and combine somatic mutations with other biological relevant data sets.
Given the ubiquitous nature of PIK3CA mutations in human cancers and the conflicting results of the above studies, the association of PIK3CA mutations with other clinical and histologic parameters is still not definitively known.
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Combinations of these mutations with others that lead to a reverse phenotype or altered inducer specificity yielded new TetR mutants with the respective combined activities.
In AML, TET2 mutations occur with other major mutations, particularly internal tandem duplication of FLT3, as well as mutations in RAS, NPM1 and DNMT3A.
Combination of a key mutation with other secondary mutations results in high level resistance.
There was no correlation of ASXL1 mutation with other gene mutations studied (Table 2).
There was no association of TP53 mutation with other chromosomal abnormalities, including +8, +11, +13, +21, −5/del 5q) and −7/del 7q).
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