Sentence examples for mutations with less from inspiring English sources

We therefore decided to test if alternative mutagens might provide a higher density of mutations with less toxicity to the treated seeds.

The most extreme form of this phenotype in cattle is seen in the Belgian Blue, while different mutations with less extreme phenotypes were identified in other breeds [ 12].

Over millions of years, an essential piece of DNA will gather few mutations compared with less important ones.

The neuroimaging profile of the C9ORF72 expansion was significantly more symmetrical than progranulin mutations with significantly less temporal lobe involvement than microtubule-associated protein tau mutations.

Proband 2 was born preterm and had the most common heterozygous CCHS PHOX2B 20/27 mutation (PARM) with less severe phenotype.

However, all methods have shown to be able to detect mutations in samples with less than 10% mutated tumour cells (Heideman et al, 2012) and all samples used for extraction had in effect more than 30% of tumour cells.

In support of this idea, Hsiao and Vitkup (2008) reported that those human genes which have a homologue with >90%% sequence similarity are ~3 times less likely to harbour disease-causing mutations than genes with less closely related homologues.

Although KRAS mutations are associated with less efficient EGFR-directed targeted therapy in various cancer types, it is not yet known if the same is true in BTC [ 21, 22].

The proportion of EGFR TK mutations in patients with less than 20 pack year exposure was 55% versus 27% for 20 50 pack years and 22% for >50 pack years (P < 0.001) [38].

It has been suggested that multiple exon deletion is associated with the early-onset, more severe form of the disorder, whereas missense mutations are associated with less severe cognitive deficits and a lower rate of movement disorders (Leen et al., 2010).

Mutation of p53 correlated with aggressive HCC and poor prognosis [ 24, 25], whereas β-catenin mutation was associated with less tumor aggression and more favorable prognosis [ 17].