Sentence examples for mutations with large from inspiring English sources

All the same, beneficial mutations with large effects do appear, just much, much less frequently.

For instance: is it the case that most beneficial mutations have small effects — and how often do beneficial mutations with large effects happen?

Sixteen deleterious substitutions were chosen among 54 known missense mutations and further ranked by stability change score into six structural and ten functional mutations with large and small stability changes, respectively.

Although these diseases are genetically and phenotypically heterogeneous, and may be caused by mutations in several genes, knowledge of mutations with large effect in sporadic cases can be used to identify candidate genes and to provide knowledge of disease pathogenesis [28, 31].

Rare mutations with large effects could be a valuable source of targets for PAGE.

Further, there appears to be better correlation for mutations with large changes in binding energy.

Good mutations with larger effects have a correspondingly larger advantage — and thus their owners are more likely to leave more descendants, and so the mutation will spread more readily.

The resulting fixation rates V depend only weakly on the effective population size N. Mutations with larger beneficial effect suffer gradually weaker interference interactions.

If mutations with larger effects on females had accumulated in the C-lines, this would diminish differences between control and MA females, making the male differential appear larger and inflating.

With the costs of DNA sequencing dropping, there is likely to be an increasing focus on identifying rare genetic variants, including structural variants such as CNVs and other rare mutations with larger risk effects.

Greater pleiotropic effects are seen for mutations with larger effects on the primary trait (48, 49), as would be anticipated for type II pleiotropic influences that are downstream effects of considerable perturbation of the primary trait.