Sentence examples for mutations with important from inspiring English sources

Thus, both genetic and demographic processes in selfing populations should lead to a decrease in the efficacy of natural selection and an increase in the fixation of slightly deleterious mutations, with important consequences for genome evolution.

Indeed, sex differences in the impact of mutation have been shown to potentially shape the deleterious mutation load, with important consequences.

The results showed that P252H mutation interferes with important colorectal cancer-associated signaling pathways such as WNT, MAPK, NOTCH, TGF-β and P53.

When coupled with genetic analysis using aCGH and whole-genome sequencing, it will be possible to identify de novo mutations that correlate with important features of cancer progression, likely revealing important insights into the crucial drivers of cancer heterogeneity.

In fact, most of our AIDS patients carry the 3′A mutation, with an important decrease in CD4 immune cells in the late stage of disease.

Lewinsohn et al. identified five novel mutations including missense mutations within important functional domains, and splicing mutations predicted to result in truncated proteins from a family with MDS/AML (Lewinsohn et al., 2016).

The sub-types defined using expression data and methylation data demonstrate considerable congruence and are also clearly correlated with mutations in important cancer genes.

Because strains maintained at high population sizes in the lab may evolve different mutations with time, it is important to point out here that PCR and Illumina sequencing have been performed on the same DNA sample extracted from the same culture at the same time.

The three mutations observed in this gene overlap with important QTLs in pig production such as back fat thickness and intramuscular fat content [ 47, 48].

We are able to extract seven sentences mentioning G12 mutations from the abstracts and substitutions of this residue are considered to be very important oncogenic mutations with clear relevance for cancer.

At the verge of entering into the era of personalized medicine, understanding the association of mutations with infectious disease is very important.