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All the same, beneficial mutations with large effects do appear, just much, much less frequently.
But they hope to spot mutations with error-detection algorithms and then go back to the original cells.
Compared to the surgical precision of modern gene editing, these efforts were like using a sledgehammer, creating potentially hundreds of unpredictable mutations with unknown effects.
For instance: is it the case that most beneficial mutations have small effects — and how often do beneficial mutations with large effects happen?
Then geneticists found out how to induce mutations with radiation and chemicals.
Mutations with small effect must be studied in large numbers of patients to be detectable.
Good mutations with larger effects have a correspondingly larger advantage — and thus their owners are more likely to leave more descendants, and so the mutation will spread more readily.
To confuse things more, Beck followed up "Mutations" with "Midnite Vultures," a postmodern minstrel show that borrows liberally from a century of African-American pop, paying tribute to black vernacular music that most white musicians would never dare to touch.
Consequently, results yielded 6 mutations with TAF23-Mu gene and 50 mutations with SPT15-Mu gene.
Extracting meaning from genetic data — matching mutations with certain diseases, for example — requires tertiary analysis.
Kapur et al. reported FLNA mutations with intestinal pseudo-obstruction.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com