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Exact(11)
Some point mutations will result in the production of antibodies that have a weaker interaction (low affinity) with their antigen than the original antibody, and some mutations will generate antibodies with a stronger interaction (high affinity).
For example, when applied to a disease-causing mutation database annotated in SwissProt, PolyPhen predicts that ∼82% of all mutations will result in damaged protein [19].
Most mutations will result in stop codons and lead to truncation of the APC gene product.
Severe mtDNA mutations will result in reproductive failure while still heteroplasmic.
Most TP53 mutations will result in changes in all three isoforms, and there are as yet no reagents for IHC that distinguish between them.
A narrow DFE with mostly neutral mutations will result in a largely drift-driven population, where the chance of survival is random (Fig. 1; upper panels).
Similar(49)
Specifically, turning off mutation will result in the emergence of a single clone.
Clearly, this mutation will result in loss of function of BACH1.
Because of the relative likelihood that these mutation will result in functional effects, often creating natural knockouts, particularly common mutations were further examined (Table 2).
Theoretically, such a mutation will result in cells that cannot recover, which can be tested by repeated pinning of the cells to measure their growth.
As XLαs, like Gs-alpha, activates cAMP signaling, it is possible that their combined loss, caused by a paternally inherited disruptive mutation, will result in a more severe phenotype.
More suggestions(15)
mutations will go
mutations will bring
mutations will lead
mutations will look
mutations will spread
mutations will tend
mutations will reduce
mutations will complement
mutations will accumulate
mutations will yield
mutations will promote
mutations will follow
mutations will confer
mutations will allow
mutations will improve
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