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This map of genetic effects is structured in a way that enables evolvability, that is, enhances the probability that mutations will improve the performance of the organism.
General adaptation to a complex environment leads to the evolution of phenotypes that have optimal net fitness ("evolved phenotype" in Fig. 7C), and this process reduces the likelihood that new phenotypes that arise from random mutations will improve fitness relative to the population as it becomes better adapted.
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The idea behind explaining the high evolvability of organisms is that the genotype phenotype maps of extant organisms are such that the probability that random mutation will improve the phenotype has increased during evolution.
The growing knowledge and understanding of the etiology and involvement of CTNNB1-mutations will improve the diagnostic process.
Increased C→T mutation bias will improve codon adaptation for the 7 U-friendly codon families, but will lead to deterioration in the 9 U-hostile codon families (Table 1).
In either scenario, understanding the genetic and lineage heterogeneity among the samples and having the chance to identify those sites, if any, that have evolved a high mutation burden will improve monitoring and treatment for that specific patient.
Therefore, studying covariation of amino acid mutations in HIV will improve our understanding of HIV drug resistance as well as help vaccine design [13], [18].
It provides an efficient and inexpensive diagnostic mutation analysis that will improve the quality of prnp genotyping compared with other low-cost methods.
Individual therapy focusing on certain gene mutations will further improve efficacy.
38 Profiling involved gastric cancer key genes, driver mutations, and interacting pathways will improve our understanding on signaling pathways network.
The proposed IBD framework will further be enhanced by accurate whole-genome sequence information, as the presence of mutations on IBD segments will improve the timing of common ancestors and IBD detection of shorter segments.
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