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Cells with these mutations will acquire resistance to EGFR TKI (Sharma et al, 2007; Stewart, 2010; Johnson et al, 2012).
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21 However, as the number of non-proliferating cells purged by replicative senescence is increased, the chance that a small number of senescent cells will acquire mutations that bypass the senescence pathway is accordingly increased.
However, if DNA uptake is biased and some of the mutations create sequences preferred by the uptake machinery, more cells will acquire these deleterious mutations than other mutations.
Phylogenetic footprinting is a comparative method based on the principle that functional sequence elements will acquire fewer mutations over time than non-functional sequences.
If resistant lines carry a fitness cost but are still allowed to evolve in the presence of the drug, natural selection will act to counterbalance the cost while preserving the resistance, and as such resistant mutants will acquire new mutations which compensate for the fitness decline.
The effectively immortalized lymphocyte may then persist in the body for years, increasing the likelihood that the cell will acquire additional mutations leading to full neoplastic transformation and the accumulation of clonal cells that may result in clinical symptoms of malignant disease (Voutsadakis 2000).
As cells divide, there's a tiny chance they will acquire a mutation.
Initially, we only have N normal cells and whenever one is selected to divide, there is a probability μ that one of the daughter cells will acquire a mutation in a specific gene.
Which, one by one, will be acquired by leading dot.coms, or will acquire them themselves.
NB will acquire the data.
If that number is below the mutation probability then mutation will take place, otherwise no mutation will occur.
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