Sentence examples for mutations which show from inspiring English sources

To understand the role of Mcl1 in kinetochore assembly, further experiments such as isolation of separation of function mutations, which show a defect in only maintenance of chromatin structures or DNA replication, might be required.

In addition, our result suggested that mutations, which show trade-offs, often are retained in parental strains.

The various correlated mutations which show consistent overlap with motif pairs are shown in Additional File 6.

Two of the most frequent domain mutations, which show resistance to Imatinib (MutY253F and E255K), responded to treatment with AZD0530.

Eight of the mutations which show kpep values slower than 0.25/s and thus appear to be rate limiting for release from EF-Tu are all mutations that have little or no effect (ΔΔ Go < 0.5 kcal/mol) on aa-tRNA binding and therefore behave similarly to the wild-type protein on the ribosome.

Utilizing the information about wild type, mutant, three neighboring residues and experimentally observed stability data, we have developed a method based on decision tree for discriminating the stabilizing and destabilizing mutants and predicting the protein stability changes upon single point mutations, which showed an accuracy of 82% and a correlation of 0.70, respectively.

It is interesting that the E. coli E259A and R288A mutations, which showed different ΔΔ Go values than in T. thermophilus, also showed different ΔΔ Go values when Phe-tRNAPhe and Tyr-tRNATyr were compared.

The results confirmed a dose-dependent increase in the ribavirin-associated transition mutations (C to U and G to A) compared with the other transition (A to G and U to C) and transversion mutations, which showed no dose dependent effect (Fig. 3c).

This is confirmed by the clinical presentation of FRDA patients carrying the p.I154F mutation, which showed earlier onset and a more aggressive phenotype when compared to p.R165P patients [19], [20].

The S313A mutation seemed to be more severe than the K312A mutation which showed a mild rescue effect on the levels of 32S precursor rRNA.

Five of 129 patients who were never smokers had the K-ras mutation, while 24 of 193 patients who were current/former smokers had the mutation, which showed significant difference (P=0.0086) (Table 3).