Sentence examples for mutations which render from inspiring English sources

Even drugs that elicit a dramatic initial response often fail later on due to the emergence of resistance mutations which render the drug ineffective.

The phenotype was specifically caused by Abp1 deficiency because cotransfecting the cells with an Abp1 construct carrying several silent mutations, which render the mRNA resistant to RNAi, restored the wild-type situation (Figure 1D).

Briefly, we hypothesized that within a starting population of cells that are chronically infected with a replication-competent subgroup B ASLV vector (encoding hygromycin B phosphotransferase) [31], there would be a subpopulation of cells containing viral variants harboring mutations which render Env unable to support low pH-dependent membrane fusion.

Importantly, these syndromes are caused by mutations which render the protein dysfunctional, but still retaining some catalytic activity.

Here we show the alpha-lactalbumin gene (LALBA), which normally encodes a milk protein involved in lactose synthesis, has undergone a number of cis-acting mutations, which render the protein absent in otariids.

In contrast, in the non-cirrhotic (DEN-induced and spontaneous) models, liver tumor formation may be mainly dependent on induced or spontaneous stochastic somatic mutations, which render some of the altered hepatocytes more proliferative than the surrounding intact hepatocytes.

The Fg-RAM cDNAs used throughout the present study have silent mutations which renders them resistant to RAM siRNA.

They made Rogue an important character because Singer recognized that her mutation, which renders her unable to touch anyone, was the most symbolic of alienation.

To determine the contribution of p110δ to neuronal development and function, we analyzed mice in which p110δ was inactivated as a result of the introduction of a germline point mutation which renders the kinase inactive (p110δD910A; [14]. Homozygous p110δD910A/D910A mice, hereafter referred to as p110δ kinase-inactive (KI) mice, are viable and fertile [14].

ON012380 also inhibited BCR-Abl with the T315I gatekeeper mutation (IC50 = 1.5 nM), a mutation which renders the kinase resistant to most ATP-competitive inhibitors.

Of particular concern is the ABL T315I 'gatekeeper' mutation, which renders leukemia cells resistant to all commercially available tyrosine kinase inhibitors other than ponatinib.