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This constant selective pressure would provide a similar means for specific subclones of the tumor cells to gain additional mutations which provided a higher growth or survival advantage over other tumor cells.
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The copy process is subject to random mutations, which provide the variation required for natural selection to occur.
The same mutations are consistently found in the three major targets of conventional insecticides despite the large number of potential mutations which provide resistance and the wide range of insects studied [ 21, 22].
The results indicated a natural match for hypoxia environments in Tibetan highlands and mild mitochondrial dysfunction caused by mtDNA deleterious mutation, which provide functional evidence for our work.
We also explored the concept of a mutation rate, which provided the opportunity to discuss central tendencies and dispersion about a mean.
The crystal structures of M. jannaschii tyrosyl-tRNA synthetase and its mutations were determined, which provided an opportunity to design aminoacyl-tRNA synthetases specific for other unnatural amino acids.
Notably, we investigated mutations to RNA polymerase, which provided a massive growth benefit but are linked to highly aberrant transcriptional profiles.
The phylogenies of both the host D. ananassae mtDNA genome as well as wAna were examined because, like the W. pipientis genome, mtDNA is also maternally inherited yet has a higher mutation rate which provides more phylogenetically informative mutations for analysis (Richardson et al. 2012; Early and Clark 2013; this study).
Among 408 such primers used, only 2 primers detected mutation sites in the revertants, which provided the molecular evidence for the revertants induced from Sdd.
Sequence information on 150 different TEM β-lactamases was derived from the TEM mutation table which provides a unique number to each protein classified as TEM β-lactamase.
In Yangze River and Huai River basin, three different coalescent-based methods, the skyline plot [ 38, 39], the estimate of population growth rate (g) using FLUCTUATE 1.4 [ 43] and the distribution of mutations conducted by GENETREE [ 44], which provided the similar information of population expansion in these regions, suggested that the superiority of the coalescent-based method.
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