Sentence examples for mutations which increase from inspiring English sources
Mutations which increase the replication of dengue viruses in cell culture would greatly facilitate the manufacture of both a live attenuated or inactivated dengue virus vaccine.
Women who have tested positive for inherited BRCA gene mutations, which increase their risk for developing a new breast cancer in their other breast, are sometimes advised to consider contralateral mastectomy.
Certain mutations, which increase affinity, are selectively favoured, while those that decrease affinity are eliminated.
Most of the reported FGFR mutations that cause heritable human diseases are activating mutations which increase receptor signaling.
HHCS is an autosomal dominant condition caused by mutations which increase expression of the ferritin light polypeptide (FTL) gene.
The comparison of polymorphisms which distinguish strains isolated before and after the introduction of vaccination (for convenience designated as pre- and post-strains) may be useful to identify mutations which increase fitness in vaccinated populations and hence reduce vaccine efficacy.
The adaptation was acquired by two mutations which increased binding (VP1 T125K) and replication (3A E41K), respectively.
Although the mechanism for this association remains elusive, some hypotheses have been proposed to explain it, including gain of function caused by GBA mutations, which increases α-synuclein (α-syn) aggregation, loss of function due to lysosomal enzyme deficiency, which affects α-syn clearance, and even a bidirectional feedback loop, but each of these hypotheses has its limitations.
Conversely, the A352D mutantmutant (a mutation which increases cGMP selectivity in eukaryotic channels) increased both the affinity and the sensitivity for cGMP relative to the WT channel, again leaving those for cAMP unchanged.
We specifically asked whether human ZnT3 harboring the Y372F mutation, which reduces the ZnT3 80 kDa species, was dominant over the Y357F mutation, which increases ZnT3 80 kDa species.
Our model explains well the effect of CDK9 S175A mutation, which increases the association of the mutant CDK9 with HEXIM1 suggesting more efficient 7SK snRNP formation.
