Sentence examples for mutations which in from inspiring English sources

The proportion of patients who had suffered DNA damage may be significant, because such changes can cause mutations which in turn lead to cancer.

The affinity of the new cloned antibodies is improved by mutations, which in turn, leads to neutralisation and elimination of the antigen.

As such, there can be something of a ratcheting effect in which beneficial mutations arise and become fixed by selection, only to be supplemented later by more beneficial mutations which, in turn, become fixed.

All the models are "multi-hit models", in that malignant lineages, with C oncogenic mutations, arise by mutation from precursor lineages with C−1 mutations, which in turn arise from precursor lineages with C−2 mutations, etc.

This dNTP imbalance interferes with mtDNA replication and results in depletion, multiple deletions, and point mutations, which in turn cause mitochondrial dysfunction.

Thus, acquisition of oncogenic changes can initiate a cycle of genomic instability that has the potential to create further mutations, which in turn may facilitate leukemic disease progression.

Small eye (Sey) in mouse is a semidominant mutation which in the homozygous condition results in the complete lack of eyes and nasal primordia.

The transgenic lines driving the excision of RB1 affect the timing of the mutation, which in turn affect the progression and competence of tumor cell.

A forward genetic screen identified the boygirl (byg) mutation, which in homozygous embryos on the C57BL/6J background causes XY gonadal sex reversal.

The F10E mutation, which in mammals replaces phenylalanine with the negatively charged glutamate, reduces both liposome binding and tubulation [9] and also disrupts curvature sensing [23].

Our data supported that the chronic CSE treatment may induce ROS production through mitochondrial mutation, which in turn upregulated PDK2 and HIF1α expression.