Sentence examples for mutations which give from inspiring English sources

The development of cancer is an evolutionary process that is driven by the acquisition of somatic genetic mutations which give cells a selective advantage against non-mutated cells [ 1].

For instance, some people have innate genetic mutations which give them exactly the same sort of edge.

In the first proposed model, as cancer cells grow and divide they acquire new mutations, which give them distinct growth and survival advantages over previous generations.

By contrast, mice carrying gain-of-function mutations in Kcnj11 (i.e. channel-open mutations), which give rise to neonatal diabetes in humans, have a phenotype that closely resembles the human disease (Koster et al., 2000).

However, the mutations which give rise to several of these polymorphisms have now been identified and genotyping assays for polymorphisms in CYP1A1, CYP2A6, CYP2D6, CYP2E1, GSTMI, and NAT2 have been developed.

On the other hand, both cases and controls received similar front-line therapies, were well balanced in terms of baseline prognostic factors and, in addition, the multivariate analysis confirmed the prognostic relevance of other well-established markers such as IGHV and TP53 mutations, which gives validity to our results.

The oncologist called me alone to the exam room, and I told her the story I had revealed to more doctors than friends: I carry the BRCA1 mutation, which gives you a 98 percent chance of developing cancer.

You learned after your mother's untimely death, and the deaths of your grandmother and aunt from cancer, that you had inherited the BRCA1 gene mutation, which gave you an 87percentt risk of developing breast cancer and a 50percentt chance of developing ovarian cancer.

A progenitor cell acquires a cancerous mutation which gives the cell a selective advantage within the microenvironment of the tissue.

Recently, it was proposed that BAALC blocks myeloid differentiation and thus requires a second mutation, which gives a proliferative advantage to induce leukemia.

However, the L164P mutation, which gives rise to unblocked currents of similar magnitude (34%) at 3 mM MgATP, also produces neonatal diabetes but not epilepsy (Tammaro et al, 2008).