These mutations found on APC are usually nonsense or frame shift mutations, which generate truncated forms of APC.
The RAM GFP constructs used throughout the present study have silent mutations which generate transcripts resistant to RAM siRNA.
However, we are primarily interested in adaptive processes under linkage in the dense-sweep regime at high rates of beneficial mutations, which generates strongly correlated clusters of fixed mutations nested in each other's background (the crossover between these regimes is further quantified below).
The functional consequence of hypertonia-associated Trak1 mutation, which generates a Trak1 mutant protein truncated at amino acid 824 (Fig. 3A), remains unknown.
Three of the complementing dpolv mutants in exon 11 are missense mutations but the complementing mutant dpolv105A is due to a nonsense mutation, and dpolv6 in exon 15 on the other side of the PIGSFEAST exon is a frameshift mutation which generates a stop codon.
Similarly, mouse models with the Osaka mutation, which generates oligomeric, but not fibrillar amyloid, develop synapse loss [ 200].
For instance, in the standard account evolutionary change begins with genetic mutation, which generates phenotypic differences that are subject to selection.
The c.649_650InsC (p.P217fsX7) mutation is a frameshift mutation, which generates a different sequence starting at position 217 and introduces a premature stop codon at position 224, generating a truncated protein with only 223 amino acids.
The minimum change required for every new band in a tumor DNA, compared to its corresponding leucocyte DNA (referred to as 'gain' in this paper) would be one mutation, which generates a perfect match, creating a primer binding site.
The importance of the anchoring residues in the HIV-1 protease was demonstrated by the F53L mutation, which generates a semiopen conformation due to removal of the stabilizing F53 I50 interaction.
