Sentence examples for mutations which does from inspiring English sources

In accordance with a previous estimation [29], one third of the simulated variants are assumed to be synonymous mutations, which does not affect gene expression and are not included in our analysis.

This mode of evolution produces temporal clustering of fixations as a generic consequence of genetic linkage and high supply of beneficial mutations, which does not depend on details of the fitness landscape (Park and Krug 2007).

This may mean that the C-terminal region of type II NDs may be able to readily undergo mutations which does not affect the catalytic activity of the protein.

While poromas exhibited only few mutations, which did not involve TP53, the majority of porocarcinomas harboured UV-mediated mutations in TP53 with some of these cases showing considerable genetic heterogeneity that may be clinically exploitable.

Notably, disease-causing mutations identified in patients with mild phenotypes might be difficult to distinguish from benign mutations, which do not cause disease.

To better define the role of PTB in the FCV life cycle and to allow the generation of mutations which did not result in large scale disruption of the RNA secondary structure, we first determined the structure of the 5' end of the FCV genomic RNA using ribonuclease (RNase) digestion.

All new mutations which did not result in amino acid residue replacement were synonymous substitutions.

Finally, mutations in PID are the only mutations which do not affect significantly the interaction between RHD and RID.

For elucidation of structure-function relationships only inactivating mutations which do not abolish expression of PglB are of interest.

However, the identification of further mutations which do not possess this ability (e.g. T617I and S505A) argued against this.

The background mutation rate is estimated based on silent mutations which do not change amino acid encoding and which are therefore considered to be passenger mutations.