Sentence examples for mutations which do from inspiring English sources

Their mutations, which do not alter RING folding, abolish PML NB assembly, demonstrating the role of tetramers in higher order of macromolecular assembly (Figs. 2 4).

We are all carriers of several such mutations, which do not harm us, but if combined with the same mutation in our partner, they create a risk that our child will be affected by a genetic disease.

Notably, disease-causing mutations identified in patients with mild phenotypes might be difficult to distinguish from benign mutations, which do not cause disease.

For elucidation of structure-function relationships only inactivating mutations which do not abolish expression of PglB are of interest.

However, the identification of further mutations which do not possess this ability (e.g. T617I and S505A) argued against this.

Finally, mutations in PID are the only mutations which do not affect significantly the interaction between RHD and RID.

While poromas exhibited only few mutations, which did not involve TP53, the majority of porocarcinomas harboured UV-mediated mutations in TP53 with some of these cases showing considerable genetic heterogeneity that may be clinically exploitable.

In accordance with a previous estimation [29], one third of the simulated variants are assumed to be synonymous mutations, which does not affect gene expression and are not included in our analysis.

To better define the role of PTB in the FCV life cycle and to allow the generation of mutations which did not result in large scale disruption of the RNA secondary structure, we first determined the structure of the 5' end of the FCV genomic RNA using ribonuclease (RNase) digestion.

All new mutations which did not result in amino acid residue replacement were synonymous substitutions.

As was the case in MPN, older age was associated with a higher incidence of TET2 mutations, which did not otherwise affect prognosis in either MDS or CMML.