Sentence examples for mutations which did from inspiring English sources

While poromas exhibited only few mutations, which did not involve TP53, the majority of porocarcinomas harboured UV-mediated mutations in TP53 with some of these cases showing considerable genetic heterogeneity that may be clinically exploitable.

To better define the role of PTB in the FCV life cycle and to allow the generation of mutations which did not result in large scale disruption of the RNA secondary structure, we first determined the structure of the 5' end of the FCV genomic RNA using ribonuclease (RNase) digestion.

All new mutations which did not result in amino acid residue replacement were synonymous substitutions.

As was the case in MPN, older age was associated with a higher incidence of TET2 mutations, which did not otherwise affect prognosis in either MDS or CMML.

In our co-immunoprecipitation experiments, this double serine mutation weakened PER2 binding to a lesser degree than the zinc finger mutations, which did not elicit a similar period-shortening effect.

This is probably due to the presence of other rare mutations, which did not pass the threshold criteria in our study (presented in more than 40% of the patients).

Notably, disease-causing mutations identified in patients with mild phenotypes might be difficult to distinguish from benign mutations, which do not cause disease.

In accordance with a previous estimation [29], one third of the simulated variants are assumed to be synonymous mutations, which does not affect gene expression and are not included in our analysis.

Finally, mutations in PID are the only mutations which do not affect significantly the interaction between RHD and RID.

For elucidation of structure-function relationships only inactivating mutations which do not abolish expression of PglB are of interest.

However, the identification of further mutations which do not possess this ability (e.g. T617I and S505A) argued against this.