Sentence examples for mutations which constitute from inspiring English sources

Furthermore, structural modeling and energetic analysis of kinase cancer mutations, which constitute the largest mutational hotspot, have provided useful insights into a common mechanism of kinase activation.

Marjamaa et al revealed four founder mutations which constitute up to 70% of the known genetic spectrum of LQTS in 6,334 Finnish subjects (Marjamaa, et al., 2009).

In this context, one should note the locations of the common AJ and Icelandic mutations, which constitute a substantial fraction of carriers in many studies.

This preprocessing includes: (i) download of genome sequences and gene annotations, (ii) unification of gene annotations among the set of considered strains, (iii) identification of gene families, (iv) computation of multiple alignments and identification of point mutations which constitute the input genotype data.

The BRAF V600E mutation, which constitutes the vast majority of all BRAF alterations detected in the thyroid, is found in approximately 45% of PTCs in Western counties [ 6] and up to 90% of those in Korea [ 1315]5].

If it is a case of the latter, an available remedy may prolong the survival but in the meantime may goad some cancer cells to develop mutations, some of which constitute the genetic bases for the upcoming contumacious phenotypes.

The realization that tumors are composed of several subclones of tumor cells that, in addition to the founder genetic events, harbor private mutations, some of which constitute bona fide driver genetic aberrations, has resulted in a paradigm shift in regards to our understanding of cancers.

Indeed DNA replication errors constitute a major source of mutations, which represent the raw material for the evolution of the genome.

All NOTCH3 mutation carriers display WM abnormalities, which constitute early signs of the disease detectable well before the occurrence of stroke, cognitive impairment and disability [ 16].

However, resequencing arrays have reduced ability to detect small deletions and insertions, which constitute ∼24% of disease-causing mutations in the Human Gene Mutation Database [27].

Carcinogenesis is simplified because mutations in oncogenes and tumour suppressor genes, which constitute multiple independent steps, are lumped into a single proliferation term.