Sentence examples for mutations which comprise from inspiring English sources

In contrast, "passenger" mutations, which comprise the majority of mutations identified, represent genetic events that have no direct or indirect effect on the selective growth advantage of the cell in which it occurred (Stratton et al., 2009; Vogelstein et al., 2013).

Taken together, these findings provide a basis for the striking decrease in global H3K27 trimethylation in the context of H3.3 variant K27M mutations, which comprise only a small percentage of total cellular H3.

Truncating mutations are distributed across the gene; however, the clustering of missense mutations, which comprise around one-third of the pathogenic mutations, defines regions of clinical significance in the protein.

The studies mentioned above have sequenced the entire ras gene while we have investigated only the codon 12 and codon 13 mutations, which comprise 90% of the mutations in the ras gene [ 33] and 20 50% of the mutations observed in the colon cancer [ 12- 14].

However, our present findings indicate that papillary carcinoma with BRAF mutation, which comprises a considerable percentage of differentiated thyroid carcinomas, might not be the major origin of anaplastic carcinoma.

In the case of the 6174delT mutation, which comprises the majority of our BRCA2 carrier population as well as in the two before-mentioned studies, part of the BRC repeat domains is still present.

We identified a previously unreported splice site mutation (Arg565Gln), which comprised the last nucleotide of exon 14 and further broadens the genetic spectrum of NTRK1 mutations.

In routine practice, KRAS mutations in codons 12 and 13 are tested, which comprise approximately 96% of the observed KRAS mutations [ 7].

This tendency is opposed by rescue mutations, all with growth rate r1 > 0, which comprise a fraction Φ of the overall genomic mutation rate U.

For our synthesis we aimed at 2 mutations per oligo, which comprised an 87-mer hairpin-loop structure plus flanking sequences.

The molecular profile of tumors might be determined by both the cell of origin as well as the particular mutation profile, in turn determining the differentiation pattern of these cells, which comprise the bulk of the tumor.