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Mutations can be classified into two categories gene, or point, mutations, which affect only a few nucleotides within a gene, and chromosomal mutations, which either change the number of chromosomes or change the number or arrangement of genes on a chromosome.
LHON has been linked to three "primary" mitochondrial DNA (mtDNA) point mutations, which affect oxidative phosphorylation in mitochondria [5], [6].
By comparing data sets for cells cultured in galactose medium vs glucose medium, we minimized the possible contribution to SPI Extremes of host cell mutations which affect growth.
Thus, in contrast with mutations which affect the function of all isoforms, mutations in exons 8 10 may display a lower penetrance and later age of onset leading to more clinical overlap with common forms of Type 2 diabetes mellitus (T2D).
This leaves a question of whether allowing mutations, which affect the generation to generation inheritance of polymerase rate, allow for a more rapid resolution of the more dominant strategy, or whether the addition of mutation to a reverse polymerase strategy causes this to be a loosing strategy when it otherwise might not be.
Thus, mutations which affect binding via the arrestin activation or phosphorylation sensors display different characteristics in the BiFC assay.
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The presence of Vi capsule or mutations which affected O-antigen synthesis (Δpmi, ΔgalE) did not decrease the sensitivity of the RapidChek® SELECT™ Salmonella assay.
We conducted a screen for genetic modifiers of an Smn phenotype using the Exelixis collection of transposon-induced mutations, which affects approximately 50% of the Drosophila genome.
A previous FBX gene phylogeny studies did not account for pseudogenes [15], but noted that a significant number of annotated A. thaliana FBX genes contain mutations, which affected the C-terminal ends of the encoded proteins.
To identify enhancers and suppressors of SMN activity and the genetic circuitry of Smn, we carried out a genetic screen for modifiers of the Smn73Ao allele using the Exelixis collection of insertional mutations, which affects approximately 50% of the Drosophila genome [24], [25], [26].
Prostate cancer cells from different individuals can carry different genetic mutations, which affects whether the disease progresses and how the tumors respond to medical treatments.
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