Sentence examples for mutations when introduced from inspiring English sources
We have shown that the very same isocitrate dehydrogenase mutations, when introduced into yeast, cause the accumulation of 2-HG, and result in epigenetic consequences.
The researchers were surprised to find that two of the mutations, when introduced into mice, led to a degenerative brain disease that proved fatal within 2 months.
Specifically, RAB-5(GDP), an inactive mutant of RAB-5 that reduces endocytosis, mimics the effect of pmk-3 mutations when introduced into wild-type animals, and occludes the effect of pmk-3 mutations when introduced into pmk-3 mutants.
These mutations, when introduced into a lung cell line, increased focus formation, formation of colonies in soft agar, cell motility, and migration.
The same mutations when introduced in the vertebrate Kinesin-1 domains also diminish the interaction between MT and the C-terminal MT binding motif (Seeger and Rice, 2010).
Studies in North American and European corvids are ongoing in order to test the relevance of the T249P substitution and several other mutations when introduced into the genome of WNV-FIN.
We show that the R704C mutation, when introduced into neuroligin-3, enhances the interaction between neuroligin-3 and AMPA receptors, increases AMPA-receptor internalization and decreases postsynaptic AMPA-receptor levels.
The single Met27Ala mutation when introduced into VAMP8 abolished the VAMP8 CALM interaction, whereas the Lys24Ala mutation on its own only weakened the interaction.
10.7554/eLife.00631.008 Figure 3. Three mutations are strongly deleterious when introduced individually into the parent Aichi/1968 NP, despite eventually becoming fixed along the evolutionary trajectory without apparent negative effect.
One intriguing possibility is that some EFHC1 mutations may be pathogenic only when introduced into specific genetic backgrounds.
We identify strain-specific mutations that are deleterious and subject to buffering when introduced individually into the ancestral genotype.
