Sentence examples for mutations when expressed from inspiring English sources

Some mutations, when expressed, will produce characteristics favourable for the organism; organisms with such favourable genes will reproduce preferentially over those without such genes.

We next tested the abilities of zinc finger arrays obtained by OPEN to induce mutations when expressed as ZFNs in somatic zebrafish cells.

S319-320A mutations, when expressed as the sole alterations to Wsc1p, caused a defect in mat formation that was not a severe as the L369A V371A mutant.

The existence of these rate differences despite identical sensitivities to mutations when expressed in bacteria suggests that there are important differences in planta.

We then determined the effective distance between the two sgRNA targets and their orientations that affected the ability of the sgRNA pairs to generate mutations when expressed in the transgenic nickase flies.

Mutating the MBD reproduces the null phenotype and expressing the TRD mutant produces milder RTT phenotypes, yet both mutations are harmless when expressed with endogenous Mecp2.

Interestingly, the E682K mutation (Fig 3A), when expressed in neuronal cultures, generated more C99 (both phosphorylated and non-phosphorylated), no detectable phosphorylated C89, and apparently less of the mixture of non-phosphorylated C89 and phosphorylated C83 compared to WT APP (Fig 3A).

It also allowed researchers to observe the effects of mutations that are lethal when expressed in the organism as a whole.

To further substantiate the biological relevance of UNC-45 oligomerization for muscle function, we tested whether the interface mutations compromised sarcomere organization when expressed in wild-type worms.

We have demonstrated that the causative mutation of HSAN1, SPT1 C133whenexpressedsed in Drosophila (as dSpt1C129W) acts dominantly to reduce sphingolipid synthesis, generate synthesis of DSBs and perturb the development of dendrites, neuromuscular synapses and nociceptive function of the class IV da sensory neurons.

These similarities strongly argue that the mutant human proteins, when expressed in C. elegans, are closely modelling a fundamental property of these mutations in humans.