He asserts that the flower undergoes a mutation when exposed to radiation.
Its target, DNA gyrase is shown previously to undergo adaptive mutation when exposed to ciprofloxacin at near MIC concentrations.
Interestingly, neutrophils and dermal fibroblasts from TRAPS patients with several different mutations undergo reduced apoptosis when exposed to TNF [ 16, 66].
Cells from humans bearing the NOD2 frameshift mutation produced less IL-1β when exposed to B. burgdorferi, indicating that this PRR is also important in Lyme disease [ 3].
For example, xeroderma pigmentosum (XP) patients possess inherited defects in nucleotide excision repair (NER) and a predilection to skin cancer, and the mutation rate is significantly elevated in their cells when exposed to UV light (Maher et al, 1979).
In the case of LQTS2, caused by mutations in the IKr channel, hiPSC-derived cardiomyocytes developed arrhythmias when exposed to isoprenaline, a stressor used clinically to precipitate and diagnose the condition [ 34].
Children with the null mutation of glutathione S-transferase enzymes are at increased risk of asthma when exposed to traffic-related pollutants (Romieu et al. 2006), and children with a specific mutation in paraoxonase-1 are more susceptible to the adverse effects of exposure to pesticides (Holland et al. 2006).
Mutation scanning with HRMA is based on the dissociation behaviour of DNA when exposed to an increasing temperature, in the presence of intercalating fluorescent dyes.
Human tumors with the mutation, grafted into mice, Plexxikon's chief scientist told Dr. Flaherty, had stopped growing when exposed to the drug.
As expected, the mice developed lung tumors when exposed to the drug, but these tumors didn't grow any faster than mouse tumors that had mutations in only one of the genes.
