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In fact, in the RIM+ alleles tested, six point mutations were widely scattered along the protein.
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Overall, MxA single-point mutations are widely spread in different human cancers, and MxA mutates more frequently in colorectal cancer according to current data.> -wrap-foot> aR655C mutation was discovered in colorectal cancer in two individual sequencing projects We then checked the conservation level of the amino acid residues mutated in cancers.
Activating mutations in one allele of an oncogene (heterozygous mutations) are widely believed to be sufficient for tumorigenesis.
The A*33-associated T242X and G248X mutations are widely known to be selected by HLA_B*57/*5801 [26], so they are likely to be reflected in the linkage disequilibrium with B*58.
While mitochondrial DNA (mtDNA) mutations are widely used in evolutionary studies, they also play a central role in apoptosis, disease and aging [1], [2].
These mutations are widely scattered across both genes.
Genetic testing to identify BRCA1/2 mutations is widely available and commonly employed.
The mutations are widely distributed along the entire protein without a dominant location.
TP53 gene mutations are widely detected in breast cancer, being correlated with specific clinical phenotypes [ 11, 12].
These mutations are widely scattered across both genes and most affect the structure and function of the gene.
Yang et al. 17 reported that artificially generated transforming mutations are widely distributed in the 3‐D structure of mTOR.
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