Sentence examples for mutations were unlikely from inspiring English sources

The close relationship between B. taurus and the successfully amplified outgroup species should mean that double mutations were unlikely.

Third chromosome mutations were unlikely to be recovered because we later learned that the eye phenotype required animals to be homozygous for the unmutagenised third chromosome carrying GMroX1-75C.

These results confirmed that frequent allelic losses of beclin 1 were part of reasons for beclin 1 down-regulation and mutations were unlikely the main regulatory mechanism for beclin 1 inactivation in breast cancer.

Although these mutations were unlikely to specifically impact compensatory growth, the possibility that they might represent a class of genes that are required more when growth is accelerated, led us to also pursue their characterization further.

The higher proliferation rate of LNCaP cells following the ectopic expression of PARD3 gene indicates that the mutations were unlikely to occur during the propagation of LNCaP cells in tissue culture; the LNCaP cells without mutations in the PARD3 gene would quickly outgrow the cells with mutations in tissue culture.

Our data suggest that TP53 mutations develop in NNEDV and are intrinsic to the clonal evolution that leads to SCC, as the multiplicity of TP53 mutational events indicate that identical mutations are unlikely to occur independently (Greenblatt et al, 1994).

Based on our findings, these rare highly-penetrant mutations are unlikely to be seen in sporadic CAA patients.

Deleterious mutations are, by definition, subject to purifying selection, while weakly beneficial mutations are unlikely to be substituted by selection because either they cannot escape drift in small populations or, in large populations, are eliminated in competition with the relatively more abundant class of non-synonymous mutations with larger beneficial effects.

Therefore, covering the majority of patients at a depth greater than 10 mutations is unlikely.

Furthermore, these results suggest that pre-existing libraries of Su var) mutations are unlikely to contain significant numbers of TPE-suppressing mutations.

However, these mutations are unlikely to mediate the evolution of Fujian-like viruses in nature since none of them occurred in either Fujian clade or Panama clade.