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For each gene pair, the mutations were totally biased towards one of the two het genes.
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The A86G mutation shows very low activity and the C and U mutations are totally inactive.
Some of these destabilizing mutations are totally neutral, while others are neutral with respect to function but promote immune escape.
Although the disease onset age of originally reported PD patients with potential HTRA2 mutations were not totally early-onset (range 49 77 years, mean 57.3 years, Strauss et al. 2005), we sequenced the complete HTRA2 coding region in a cohort of 133 Taiwanese patients with EOPD or familial PD and 150 age- and gender-matched controls in the first study set.
In addition, genotype Ia was associated with diverse mutations at VP1 loops and sites under positive selection outside loops, which were totally absent in Ib1.
We were totally, totally integrated.
You were totally unchanged.
We were totally dominant.
But we were totally wrong, people totally loved it".
In humans, the N370S mutation is associated with type 1 disease, but up to two-thirds of individuals carrying this mutation seem to be totally asymptomatic (Grabowski, 1997).
Totally 26 somatic mutations were identified in these 23 patients, among which 3 patients carried two different mutations in TP53.
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