Your English writing platform
Discover LudwigSuggestions(5)
Exact(12)
33% of mutations were synonymous and showed evidence of selection on codon usage.
In the CDS regions, 29 and 31 mutations were synonymous and nonsynonymous substitutions, respectively.
In Cambodia, all mutations were synonymous, and likewise all but one sample from Thailand had only synonymous SNPs.
Most of the mutations were synonymous, suggesting that the vast majority of coding changes result in inviable genomes.
Sixty-five mutations were synonymous and 46 non-synonymous.
Three of 12 novel mutations were synonymous, whereas nine were non-synonymous.
Similar(48)
However, this approach is not appropriate for conserved genes in which most mutations are synonymous and a very small number of changes can still be adaptive [ 54, 55].
Given that a majority of all possible synonymous mutations are transitions, the Ts/Tv ratio was also calculated for all mutations at 4-fold degenerate (4D) codon sites, where all possible mutations are synonymous.
Specifically, if the mutation is synonymous in both ORFs, its fixation probability is set to be a (0 < a < 1); if the mutation is synonymous to ORF1 but nonsynonymous to ORF2, its fixation probability is aω2; if the mutation is synonymous to ORF2 but nonsynonymous to ORF1, its fixation probability is aω1; if the mutation is nonsynonymous to both ORFs, its fixation probability is aω1ω2.
Of these 12 mutations, seven were non-synonymous mutations, two were nonsense mutations, two were synonymous mutations in the coding region, and one was located in the intergenic region (Table 2).
Deduced amino acid sequences were obtained with ClustalW [29] to determine whether the mutations identified were synonymous.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com