Sentence examples for mutations were sufficient from inspiring English sources
In each case, a small number of designed mutations were sufficient to cause these domains to aggregate, and in two cases, to create bona fide prion activity.
These point mutations were sufficient to completely abrogate luciferase expression in both Scp-2 and MDA-MB-231 cells.
Transfectants were analyzed for effects of PXN mutations and to test if the mutations were sufficient for transformation into cancer-like cells.
Focusing on the engineered NCI-N87 cells, the single point mutations were sufficient to shift sensitivity from the lapatinib to the AKTi-containing treatments.
Resistance emerged first in species in which single mutations were sufficient to cause clinically important levels of resistance (e.g., Staphylococcus aureus and Pseudomonas aeruginosa).
However, whereas upon differentiation wild-type hESCs efficiently silence TERT transcription, resulting in loss of telomerase activity and telomere shortening, the cancer-associated TERT promoter mutations were sufficient to maintain expression of TERT and resulted in telomerase activity levels comparable to immortal cancer cell lines.
Together our data suggest that specific genome-instability mutations are sufficient to drive discrete mutational signatures, some of which share properties with mutation patterns seen in tumors.
Results indicated that although these five mutations are sufficient for tumor development, additional molecular lesions are required for invasive behavior.
Subsequent studies using the small- and larger-fruited NILs indicated that heterochronic regulatory mutations are sufficient for explaining allelic differences in fw2.2 [18].
If the number of viral mutations was sufficient (n≥3), comparisons of continuous outcomes between two groups were based on Mann-Whitney Rank Sum tests.
In the present study, full sequencing of the optimized bacteriophage revealed that only two single nucleotide mutations are sufficient to improve its virulence towards a clinical strain.
