But others suggest that the mutations are simply a byproduct of the cancer; they note that people with mitochondrial diseases are not particularly cancer-prone, and cancer risk is not inherited maternally, as would be expected for a disease linked to mitochondria.
Hence Kimura proposed that the vast majority of mutations are simply not under selection and just drift to either fixation or extinction [ 121].
In the quasi-species regime the probability that binding site i has a mutation is simply given by a s i, as given by Equation 5.
Because the SNP assays are known to be polymorphic in B. taurus, the probability of a double mutation is simply the probability of a mutation at the same base in the lineage leading to Banteng, Bison and Yak.
The authors of the mutation report emphasize that a familial incidence was not investigated and that they could "not exclude that the mutation is simply a rare polymorphism without any phenotypical relevance" [ 21].
Dr. Spaulding said that not enough was known about Didymo to say whether its recent geographic spread and more aggressive behavior were caused by environmental changes or genetic mutations, or were simply part of a natural cycle that had never been observed.
It should be noted that the approach followed here was relatively simplistic and that it is very possible that the mutations made were simply not the correct ones required to improve thermostability.
For one, the researchers were unable to confirm that the mutations were not simply genotyping errors for eight of the 13 individuals.
But Dr. Valiant argues that if all the mutations that drive evolution were simply random and equally distributed, it would proceed at an impossibly slow and inefficient pace.
Therefore, the effects of MRE β-loop mutations cannot be simply explained by the intrinsic susceptibility of these substrates to RseP.
