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Here, non-816 c-kit mutations were rarely found in adults' onset patients (2%), whereas it represented 25% of patients with age of onset below 5 years old and 0% of patients with an age of onset between 5 and 15 years.
Mutations were rarely seen in gene overlapping regions.
Deletion or insertion mutations were rarely identified during saturation mutagenesis of the bop promoter.
PIK3CA and RAS mutations were rarely found in our series [ 12].
Unlike C-NHEJ, MMEJ junctions did not show any insertions, although point mutations were rarely seen.
These DHPS gene mutations were rarely found in clinical isolates before the early 1990s (19, 20, 22 ).
Similar(45)
There are no clear mutational hotspots, and mutations are rarely recurrent among the usually compound heterozygous patients.
The majority of these tumours express low levels of p53, and TP53 mutations are rarely observed.
These mutations are rarely gained or lost at relapse, and the latter 2 mutations are observed in elderly subjects with mosaic hematopoiesis antedating overt leukemia.
It is our understanding that unselected mutations are rarely fixed in such populations.
From an epigenetic viewpoint, it is also noteworthy that inactivation of FOXL2 in juvenile OGCT cases is correlated with tumor mitotic index and aggressivity, although FOXL2 mutations are rarely present [11], [12].
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