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The chromosomal position of called mutations were processed using YeastMine Genomic DNA Search function (Balakrishnan et al. 2012) to determine whether the mutations fell within genes and whether the same gene was mutated in all six isolates.
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Both mutations are processes that biologists can explore to learn about the causes of schizophrenia, and possibly other mental problems.
For the analysis of POLE, 56 cases were excluded from sequencing due to poor DNA quality so as to 373 samples were processed for mutation analysis.
ROC curves for these comparisons are depicted in Additional file 1: Figure S1.> -wrap-foot> *test test is based on a subset of Swiss-Prot dataset of which mutations can be processed by both EFIN and PolyPhen-2.
*This test is based on a subset of Swiss-Prot, of which mutations can be processed by all these 5 tools, including totally 18660 damaging variants and 28863 neutral variants.
How this mutation information is processed further varies depending on the various testsuites.
[ 16- 18] However, unlike HNSCC, the functional loss of TP53 in CC is not ascribed to gene mutation, but is processed by viral and host protein-protein interaction.
5 Previous studies suggested that specific mutations (G130V, I154F) might be processed differently by mitochondrial processing peptidase, thus affecting their ability to enter mitochondria.
Selection, mutation: After the evaluation, the selection and the mutation of the populations are processed.
The ∼75% reduction in full-length GRN, suggests an unbalanced GRN metabolism in loss-of-function mutation carriers whereby more GRN is processed into granulins.
For a negative control, wild-type plaques with no expected mutations were collected and processed for sequencing.
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