Sentence examples for mutations were positioned from inspiring English sources

All mutations were positioned in two FBN1 exons that encode the fourth TGFβ binding protein-like domain (TB4).

Mds3p displays four nonsynonymous mutations with respect to the two parental strains, and two mutations are positioned in N-terminus protein.

These mutations are positioned throughout XIAP and almost invariably interfere with the integrity of the C-terminal RING domain (Fig 1A).

Most of these mutations are positioned in the vicinity of the β- and γ-secretase cleavage sites (exons 16 and 17 of APP); therefore, they influence APP proteolytic processing and/or aggregation.

The missense mutation is positioned at codon 185, C-terminal of the transmembrane domain (codon 97 117).

The R149G mutation is positioned on the helix-turn-helix motif of ParB and might thus directly affect binding to parS sites (Leonard et al., 2004).

The HCM/DCM mutant Arg975Trp has profound effects on the binding of metavinculin to actin [7], indicating that this mutation, which is positioned within α-helix H1', should have substantial consequences on metavinculin structure.

However, the mutation G387E (G387 is positioned on the enzyme surface) was spontaneous since it was not included in the library.

It rather suggests that mutation hotspots are positioned in a long-term evolutionary process that is constantly receiving feedback from natural selection, and they never take on the role of natural selection.

Notably, these mutations were at similarly positioned residues to those identified in PPP2R5D (Fig.  1A).

Three of these 9 mutations were at positions 16, 18, and 22 in the isolates from China; they influenced the hydrophobicity of the S protein as compared with that for CV777 (Technical Appendix Figure, panel B).