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Two Fleckvieh-specific mutations were perfectly associated with FH2.
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Interestingly these mutations are perfectly mutually exclusive with those targeting PIK3CA.
We discovered an allelic series of loss of function mutations affecting our R2R3 gene candidate, and the presence of any of the four loss of function mutations was perfectly correlated with the brown seed coat/hilum phenotype in a broad distribution of soybean cultivars divergent in seed coat, hilum and flower color.
The presence of any one of these mutations was perfectly correlated with the brown seed coat/hilum phenotype in a broadly distributed survey of soybean cultivars, barring the presence of the epistatic dominant I allele or gray pubescence, both of which can mask the effect of the r allele, resulting in yellow or buff hila.
This mutation is perfectly segregating with the disease phenotype in pedigree.
In our study, the rs475678587 A mutation was perfectly associated with AH1.
The p.W125X-mutation was perfectly associated in a panel of 3,650 animals, further substantiating our suspicion of causality.
Significantly, Cdc13 Est1 fusions containing either the cdc13-2 mutatior or a telomerase-minus mutation in Est1 were perfectly capable of telomere maintenance.
Although his arguments were clearly valid for weakly deleterious co-recessive mutations, we now know that a very large proportion of deleterious mutations will be perfectly recessive and that mut/WT heterozygotes will show very little, if any, reduction in fitness compared to WT homozygotes [ 29, 30].
They were perfectly legal".
All IPCs were perfectly amplified.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com