Myriad collects data regarding the clinical outcome associated with that VUS, and a VUS may ultimately be reclassified as deleterious or neutral as more is learned; conversely, deleterious or neutral mutations are occasionally reclassified as VUSs.
Somatic hyper-mutations were occasionally detected in all framework regions (FR) and complementary determining regions (CDR), and most of the BCR diversity was the result of N-additions in the CDR3 region.
In summary, BRAFV600E mutation was occasionally observed in anaplastic carcinomas with papillary carcinoma, and the low frequency of BRAFV600E mutation in anaplastic carcinoma was thought to be due to the low frequency of anaplastic carcinomas with papillary carcinoma.
Plants bearing the cdka;1 mutation are occasionally defective in germ-cell division, and thus fail to produce the two sperm cells necessary for the double fertilization [ 74, 76- 78].
(As is often true for sequences in combinatorial libraries, spurious mutations were observed occasionally, but these do not interfere with the overall binary pattern – see Figure S2).
Moreover, BRAF activating mutations have been occasionally detected in both EWS-ATF1 positive and negative CCS [ 8, 12, 13].
In our study, all the mutations found differed from those reported in Cambodia, and mutant alleles were not always observed in the proceeding seasons, so some mutations could be occasionally introduced.
Seeds were occasionally transported over longer distances.
Occasionally, mutations were detected in cancer metastases that were different from the primary tumor, but no mutations emerged as singular drivers of metastasis.
Although the R450H mutation in TSHR is occasionally observed in Japanese pediatric patients with TSH resistance, the frequency of this mutation in the general population of Japanese adults has not been reported until now.
