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In contrast to previous reports, the mutation rates did not differ by HPV status, although transversions at CpG sites were more frequent in HPV tumours and a predominance of TpC mutations were noted in HPV cases3 (Supplementary Fig. 1.1).
Optineurin mutations were noted to vary with ethnic background [7].
These sequences were aligned with rCRS and the mutations were noted [16].
On NGS, 26 mutations were noted in 15 cases.
On NGS, 26 mutations were noted in 15 cases (Tables 3).
KRAS mutation was investigated in 205 patients and mutations were noted in 88 of those patients (42.9%).
Similar(44)
For the T[5-Me,8]G cross-link, a similar pattern of mutations was noted, but the mutational frequency was significantly higher than that of G[8,5-Me]T.
For the T[5-Me,8]G cross-link, altheugh the mutational frequency increased, a similar pattern of mutations was noted.
It is interesting to note that while, on the top strand, the G residues at the first position of the GYW or the second position of the RGYW motifs were significantly more mutated in NBS patients, no alteration in the rate of mutations was noted in the corresponding C residues at the reverse complementary motifs (WRC or WRCY; Table 2, Fig. 2 and Table S3).
As shown in Figure 3, a substantial increase in private site mutations was noted in these subjects (Figure 3A), especially over the first 56 days of treatment (Figure 3B, p = 0.038).
Splice site and branch point mutations are noted as in 3C.
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